Manager, Payroll & Stock Administration

Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed. The Opportunity Praxis is hiring a Manager, Payroll & Stock Plan Administration, to own and evolve the systems that ensure our people are paid accurately and understand the value of their equity. This role sits at the center of employee trust and company compliance. You will operate as a hands-on individual contributor, fully accountable for U.S. payroll and stock plan administration in a public company environment. Beyond execution, you will design and scale processes that enable speed while maintaining strong internal controls. This role is responsible for building and continuously strengthening SOX-compliant, audit-ready infrastructure. Success means not just passing audits, but creating systems that are durable, efficient, and built to scale with the company. You will challenge existing processes, identify gaps, and proactively improve systems rather than simply maintain them. The ideal candidate brings deep payroll expertise, strong judgment, and a track record of improving controlled environments without slowing them down. Success in this role means delivering near-zero payroll errors, maintaining audit-ready systems at all times, and continuously improving processes as the company scales. Primary Responsibilities Own end-to-end U.S. multi-state payroll processing, ensuring accuracy, timeliness, and full regulatory compliance Administer equity programs including stock options, RSUs, and ESPP across the full lifecycle Partner with Fidelity or similar platforms to manage equity operations and maintain data integrity Design and maintain SOX-compliant payroll and equity controls, including documentation, reconciliations, and audit support Build and continuously strengthen audit-ready infrastructure that scales with company growth Improve payroll and equity workflows to increase efficiency while maintaining strong controls Ensure compliance with federal, state, and local payroll tax regulations, filings, and reporting Maintain and reconcile data across payroll, equity, HRIS, and finance systems Serve as a trusted resource for employees, resolving payroll and equity questions clearly and quickly Partner with Finance, People, Legal, and external auditors to ensure alignment and audit readiness Qualifications and Key Success Factors Bachelor’s degree in Accounting, Finance, Business, or a related field (or equivalent experience). 6–10+ years of relevant payroll experience, including significant exposure to stock plan administration. Strong knowledge of U.S. payroll regulations, tax compliance, and reporting requirements. Proven experience identifying control gaps and implementing improvements in a SOX-regulated environment Experience supporting external audits and interacting directly with auditors Experience with equity administration platforms—Fidelity strongly preferred. Experience with payroll systems such as Paycom (preferred) or similar platforms. Demonstrated ability to independently own and improve critical processes in a high-accountability environment. The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Annualized Base Salary $125,000—$145,000 USD Company Overview Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to [email protected]. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.